Abstract Covalent drugs can achieve high potency with long dosing intervals. However. concerns remain about side-effects associated with off-target reactivity. Combining macrocyclic peptides with covalent warheads provides a solution to minimise off-target reactivity: the peptide enables highly specific target binding. https://www.diegojavierfares.com/deal-time-Hybrid-Racing-V3-Short-Shifter-Assembly-02-06-RSX-K-Swap-flash-save/